BGC > Product Search > Dasatinib | 302962-49-8

Molecular Formula: C22H28ClN7O3S
Molecular Weight: 488.01
HS Code: 29341000

Molecular Formula: C22H28ClN7O3S
Molecular Weight: 488.01
HS Code: 29341000

Molecular Formula: C22H28ClN7O3S
Molecular Weight: 488.01
HS Code: 29341000

Molecular Formula: C22H28ClN7O3S
Molecular Weight: 488.01
HS Code: 29341000

Description :
Dasatinib, also known as BMS-354825, is an orally bioavailable synthetic small molecule-inhibitor of SRC-family protein-tyrosine kinases. Dasatinib binds to and inhibits the growth-promoting activities of these kinases. Apparently because of its less stringent binding affinity for the BCR-ABL kinase, dasatinib has been shown to overcome the resistance to imatinib of chronic myeloid leukemia (CML) cells harboring BCR-ABL kinase domain point mutations. SRC-family protein-tyrosine kinases interact with variety of cell-surface receptors and participate in intracellular signal transduction pathways; tumorigenic forms can occur through altered regulation or expression of the endogenous protein and by way of virally-encoded kinase genes.

• Molecular Weight :488.01
• Melting Point :> 250°C (dec.)
• Purity :> 98%

Molecular Formula :
C22H26ClN7O2S
Canonical SMILES :
CC1=C(C(=CC=C1)Cl)NC(=O)C2=CN=C(S2)NC3=NC(=NC(=C3)N4CCN(CC4)CCO)C
InChI :
InChI=1S/C22H26ClN7O2S/c1-14-4-3-5-16(23)20(14)28-21(32)17-13-24-22(33-17)27-18-12-19(26-15(2)25-18)30-8-6-29(7-9-30)10-11-31/h3-5,12-13,31H,6-11H2,1-2H3,(H,28,32)(H,24,25,26,27)
InChIKey :
ZBNZXTGUTAYRHI-UHFFFAOYSA-N
Appearance :
White to Off-White Solid
Synonyms :
BMS-354825; BMS354825; BMS354825

More details are to be found here

Description :
Dasatinib, also known as BMS-354825, is an orally bioavailable synthetic small molecule-inhibitor of SRC-family protein-tyrosine kinases. Dasatinib binds to and inhibits the growth-promoting activities of these kinases. Apparently because of its less stringent binding affinity for the BCR-ABL kinase, dasatinib has been shown to overcome the resistance to imatinib of chronic myeloid leukemia (CML) cells harboring BCR-ABL kinase domain point mutations. SRC-family protein-tyrosine kinases interact with variety of cell-surface receptors and participate in intracellular signal transduction pathways; tumorigenic forms can occur through altered regulation or expression of the endogenous protein and by way of virally-encoded kinase genes.

• Molecular Weight :488.01
• Melting Point :> 250°C (dec.)
• Purity :> 98%

Molecular Formula :
C22H26ClN7O2S
Canonical SMILES :
CC1=C(C(=CC=C1)Cl)NC(=O)C2=CN=C(S2)NC3=NC(=NC(=C3)N4CCN(CC4)CCO)C
InChI :
InChI=1S/C22H26ClN7O2S/c1-14-4-3-5-16(23)20(14)28-21(32)17-13-24-22(33-17)27-18-12-19(26-15(2)25-18)30-8-6-29(7-9-30)10-11-31/h3-5,12-13,31H,6-11H2,1-2H3,(H,28,32)(H,24,25,26,27)
InChIKey :
ZBNZXTGUTAYRHI-UHFFFAOYSA-N
Appearance :
White to Off-White Solid
Synonyms :
BMS-354825; BMS354825; BMS354825

More details are to be found here

Purity : 98%
Smile code : O=C(C1=CN=C(NC2=NC(C)=NC(N3CCN(CCO)CC3)=C2)S1)NC4=C(C)C=CC=C4Cl
MDL Number : MFCD11046566
MolFormula : C22H26ClN7O2S
MolWeight : 488.0055
Available in stock : 638.664

More details are to be found here

Smile code:
O=C(C1=CN=C(NC2=NC(C)=NC(N3CCN(CCO)CC3)=C2)S1)NC4=C(C)C=CC=C4Cl
MDL Number:
MFCD11046566
Purity :
98%
Available in stock:
461.662 g

More details are to be found here

Smile code:
O=C(C1=CN=C(NC2=NC(C)=NC(N3CCN(CCO)CC3)=C2)S1)NC4=C(C)C=CC=C4Cl
MDL Number:
MFCD11046566
Purity :
98%
Available in stock:
461.662 g

More details are to be found here

Smile code:
O=C(C1=CN=C(NC2=NC(C)=NC(N3CCN(CCO)CC3)=C2)S1)NC4=C(C)C=CC=C4Cl
MDL Number:
MFCD11046566
Purity :
98%
Available in stock:
461.662 g

More details are to be found here

Formula:
C22H26ClN7O2S
Mol Weight:
488,01g/mol

Formula:
C22H26ClN7O2S
Mol Weight:
488,01g/mol

Formula:
C22H26ClN7O2S
Mol Weight:
488,01g/mol

Formula:
C22H26ClN7O2S
Mol Weight:
488,01g/mol

Formula:
C22H26ClN7O2S
Mol Weight:
488,01g/mol