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Suppliers for
Regorafenib
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Properties | CAS |
755037-03-7 | Formula |
C21H15ClF4N4O3 |
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13 Registered suppliers
Molecular Formula: C21H15ClF4N4O3 Molecular Weight: 482.8154128 HS Code: 29242990
Molecular Formula: C21H15ClF4N4O3 Molecular Weight: 482.8154128 HS Code: 29242990
Molecular Formula: C21H15ClF4N4O3 Molecular Weight: 482.8154128 HS Code: 29242990
Molecular Formula: C21H15ClF4N4O3 Molecular Weight: 482.8154128 HS Code: 29242990
Description : Regorafenib, also known as BAY 73-4506, is an orally bioavailable small molecule with potential antiangiogenic and antineoplastic activities. Regorafenib binds to and inhibits vascular endothelial growth factor receptors (VEGFRs) 2 and 3, and Ret, Kit, PDGFR and Raf kinases, which may result in the inhibition of tumor angiogenesis and tumor cell proliferation. VEGFRs are receptor tyrosine kinases that play important roles in tumor angiogenesis; the receptor tyrosine kinases RET, KIT, and PDGFR, and the serine/threonine-specific Raf kinase are involved in tumor cell signaling. Regorafenib is demonstrated to increase the overall survival of patients with metastatic colorectal cancer and has been approved by the US FDA on September 27, 2012. - Molecular Weight :482.83
- Boiling Point :513.4±50.0°C (Predicted)
- Melting Point :203-205°C
- Purity :> 98%
Molecular Formula : C21H15ClF4N4O3 Canonical SMILES : CNC(=O)C1=NC=CC(=C1)OC2=CC(=C(C=C2)NC(=O)NC3=CC(=C(C=C3)Cl)C(F)(F)F)F InChI : InChI=1S/C21H15ClF4N4O3/c1-27-19(31)18-10-13(6-7-28-18)33-12-3-5-17(16(23)9-12)30-20(32)29-11-2-4-15(22)14(8-11)21(24,25)26/h2-10H,1H3,(H,27,31)(H2,29,30,32) InChIKey : FNHKPVJBJVTLMP-UHFFFAOYSA-N Solubility : Soluble in DMSO (Slightly), Methanol (Slightly) Appearance : Pale Pink to Light Pink Solid Application : antineoplastic agent Storage : Store at 2-8°C Synonyms : 4-[4-[[[[4-Chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-3-fluorophenoxy]-N-methyl-2-pyridinecarboxamide; 4-[4-[N'-(4-Chloro-3-trifluoromethylphenyl)ureido]-3-fluorophenoxy]pyridine-2-carboxylic Acid Methylamide; Regorafenibum; Stivarga; 4-(4-(3-(4-Chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenoxy)-N-methylpicolinamide; BAY 73-4506; BAY 734506; BAY734506; BAY-734506
More details are to be found here
MDL: MFCD16038047 MF: C21H15CLF4N4O3 MW: 482,82
More details are to be found here
More details are to be found here
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Properties:
... more properties and specification on Regorafenib
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Last update 2024-06-03
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