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Suppliers for
Camptothecin
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Properties | CAS |
7689-03-4 | Formula |
C20H16N2O4 |
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15 Registered suppliers
Purity : 98% Smile code : [C@@]5(C2=C(C(N1CC4=C(C1=C2)N=C3C=CC=CC3=C4)=O)COC5=O)(CC)O MDL Number : MFCD00081076 MolFormula : C20H16N2O4 MolWeight : 348.3521 Available in stock : 1384.784
More details are to be found here
Purity : 98% Smile code : [C@@]5(C2=C(C(N1CC4=C(C1=C2)N=C3C=CC=CC3=C4)=O)COC5=O)(CC)O MDL Number : MFCD00081076 MolFormula : C20H16N2O4 MolWeight : 348.3521 Available in stock : 1384.784
More details are to be found here
More details are to be found here
Product Name: (+)-Camptothecin CAS: 7689-03-4 MF: C20H16N2O4 MW: 348.35 EINECS: 444-280-6 Mp: 260 °C (Dec.)(Lit.) Storage Temp.: 2-8°C Solubility: Chloroform/Methanol (4:1): 4 Mg/Ml Form: Solid Color: Yellow Water Solubility: Insoluble Merck: 1735 Chemical Properties light yellow crystal powde Usage :antineoplastic Usage : Antitumor agent;Topoisomerase I inhibitor Usage: 10-hydroxycamptothecine precursor, topoisomerase inhibitor, binds irreversibly to DNA-topoisomerase I complex Usage :Antitumor alkaloid. Binds irreversible to the DNA-topoisomerase I complex, inhibiting the reassociation of DNA after cleavage by topoisomerase I and traps the enzyme in a covalent linkage with DNA. A cytotoxic antitumor agent Biological Activity: Cytotoxic plant alkaloid with antitumor properties; prototypic DNA topoisomerase I inhibitor.
Camptothecin is an alkaloid derived from the Chinese tree Camptotheca acuminata Decne. Camptothecin and its derivatives are unique in their ability to inhibit DNA Topoisomerase I, by stabilizing a covalent reaction intermediate termed the cleavable complex which ultimately causes tumor cell death.
In clinical settings it is widely believed that camptothecin analogs exhibited remarkable anti-tumor and anti-leukaemia activity. Topoisomerase is a basilic enzyme in the process of DNA replication responsible for the winding / unwinding of the super-coiled DNA composing the chromosomes. If the chromosomes cannot be unwound, transcription of DNA messages cannot occur so that the protein cannot be synthesized, which ultimately causes cell death.
Application of camptothecin in clinical settings is limited due to serious side effects and poor water-solubility. At present, some camptothecin analogs—either semi-synthetic or synthetic drugs based on camptothecin—have been applied as cancerous therapy such as topotecan and irinotecan, while others have obtained satisfying curative effects in clinical applications.
Camptothecin is an alkaloid derived from the Chinese tree Camptotheca acuminata Decne. Camptothecin and its derivatives are unique in their ability to inhibit DNA Topoisomerase I, by stabilizing a covalent reaction intermediate termed the cleavable complex which ultimately causes tumor cell death.
In clinical settings it is widely believed that camptothecin analogs exhibited remarkable anti-tumor and anti-leukaemia activity. Topoisomerase is a basilic enzyme in the process of DNA replication responsible for the winding / unwinding of the super-coiled DNA composing the chromosomes. If the chromosomes cannot be unwound, transcription of DNA messages cannot occur so that the protein cannot be synthesized, which ultimately causes cell death.
Application of camptothecin in clinical settings is limited due to serious side effects and poor water-solubility. At present, some camptothecin analogs—either semi-synthetic or synthetic drugs based on camptothecin—have been applied as cancerous therapy such as topotecan and irinotecan, while others have obtained satisfying curative effects in clinical applications.
Camptothecin is an alkaloid derived from the Chinese tree Camptotheca acuminata Decne. Camptothecin and its derivatives are unique in their ability to inhibit DNA Topoisomerase I, by stabilizing a covalent reaction intermediate termed the cleavable complex which ultimately causes tumor cell death.
In clinical settings it is widely believed that camptothecin analogs exhibited remarkable anti-tumor and anti-leukaemia activity. Topoisomerase is a basilic enzyme in the process of DNA replication responsible for the winding / unwinding of the super-coiled DNA composing the chromosomes. If the chromosomes cannot be unwound, transcription of DNA messages cannot occur so that the protein cannot be synthesized, which ultimately causes cell death.
Application of camptothecin in clinical settings is limited due to serious side effects and poor water-solubility. At present, some camptothecin analogs—either semi-synthetic or synthetic drugs based on camptothecin—have been applied as cancerous therapy such as topotecan and irinotecan, while others have obtained satisfying curative effects in clinical applications.
Camptothecin is an alkaloid derived from the Chinese tree Camptotheca acuminata Decne. Camptothecin and its derivatives are unique in their ability to inhibit DNA Topoisomerase I, by stabilizing a covalent reaction intermediate termed the cleavable complex which ultimately causes tumor cell death.
In clinical settings it is widely believed that camptothecin analogs exhibited remarkable anti-tumor and anti-leukaemia activity. Topoisomerase is a basilic enzyme in the process of DNA replication responsible for the winding / unwinding of the super-coiled DNA composing the chromosomes. If the chromosomes cannot be unwound, transcription of DNA messages cannot occur so that the protein cannot be synthesized, which ultimately causes cell death.
Application of camptothecin in clinical settings is limited due to serious side effects and poor water-solubility. At present, some camptothecin analogs—either semi-synthetic or synthetic drugs based on camptothecin—have been applied as cancerous therapy such as topotecan and irinotecan, while others have obtained satisfying curative effects in clinical applications.
Camptothecin is an alkaloid derived from the Chinese tree Camptotheca acuminata Decne. Camptothecin and its derivatives are unique in their ability to inhibit DNA Topoisomerase I, by stabilizing a covalent reaction intermediate termed the cleavable complex which ultimately causes tumor cell death.
In clinical settings it is widely believed that camptothecin analogs exhibited remarkable anti-tumor and anti-leukaemia activity. Topoisomerase is a basilic enzyme in the process of DNA replication responsible for the winding / unwinding of the super-coiled DNA composing the chromosomes. If the chromosomes cannot be unwound, transcription of DNA messages cannot occur so that the protein cannot be synthesized, which ultimately causes cell death.
Application of camptothecin in clinical settings is limited due to serious side effects and poor water-solubility. At present, some camptothecin analogs—either semi-synthetic or synthetic drugs based on camptothecin—have been applied as cancerous therapy such as topotecan and irinotecan, while others have obtained satisfying curative effects in clinical applications.
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Properties:
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Last update 2024-06-12
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