BGC > Product Search > 8-Fluoro-2-(4-((methylamino)methyl)phenyl)-4,5-dihydro-1H-azepino[5,4,3-cd]indol-6(3H)-one | 283173-50-2
Suppliers for CAS
283173-50-2
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Properties | CAS |
283173-50-2 | Formula |
C19H18FN3O |
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10 Registered suppliers
Amadis Chemical Company Limited
P.R.China
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Hangzhou Meite Industry Co., Ltd (Hangzhou Meite Chemical Co., Ltd)
P.R.China
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Capot Chemical Co., Ltd.
P.R.China
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Leap Chem Co., Ltd
P.R.China
Molecular Formula: C19H18FN3O
Molecular Formula: C19H18FN3O Molecular Weight: 323.36
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Finetech Industry Limited
P.R.China
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BOC Sciences
USA
Description : Rucaparib, also named as AG-014699 or PF-01367338, is a poly (ADP ribose) polymerase (PARP) inhibitor. PARP is a DNA damage-activated nuclear enzyme that has a key signaling role in the base excision repair pathway. So, rucaparib has been also found to be most effective in cells deficient in DNA repair, where the cells deficient are caused by exposure to genotoxic agents, such as irradiation produces DNA damage and its toxicity is augmented when the DNA repair is impaired. Increased radiosensitivity in presence of rucaparib was associated with persistent DNA breaks as determined by gamma-H2AX and p53BP1 foci. Rucaparib radiosensitizes prostate cancer cells, most effectively those that are PTEN-deficient and are expressing ETS gene fusion proteins, which inhibits NHEJ DNA repair. - Molecular Weight :323.36
- Purity :> 98%
Molecular Formula : C19H18FN3O Canonical SMILES : O=C1NCCC2=C(C3=CC=C(CNC)C=C3)NC4=C2C1=CC(F)=C4 InChI : 1S/C19H18FN3O/c1-21-10-11-2-4-12(5-3-11)18-14-6-7-22-19(24)15-8-13(20)9-16(23-18)17(14)15/h2-5,8-9,21,23H,6-7,10H2,1H3,(H,22,24) InChIKey : HMABYWSNWIZPAG-UHFFFAOYSA-N Solubility : 10 mM in DMSO Appearance : Solid powder Application : cancer therapy Synonyms : 8-Fluoro-2-(4-((methylamino)methyl)phenyl)-1,3,4,5-tetrahydro-6H-azepino(5,4,3-cd)indol-6-one; Rucaparib free base, AG-14447; AG 14447; AG14447; Rubraca
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Allfluoro Pharmaceutical Co. Ltd.
P.R.China
MF: C19H18FN3O MW: 323,36
Ambeed, Inc.
USA
Purity : 98% Smile code : O=C1NCCC2=C(C3=CC=C(CNC)C=C3)NC4=C2C1=CC(F)=C4 MDL Number : MFCD11977252 MolFormula : C19H18FN3O MolWeight : 323.3641 Available in stock : 38.671
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BLD Pharmatech Ltd
P.R.China
Smile code: O=C1NCCC2=C(C3=CC=C(CNC)C=C3)NC4=C2C1=CC(F)=C4 MDL Number: MFCD11977252 Purity : 98% Available in stock: 37.04 g
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Chemlyte Solutions
P.R.China
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